Genodermatoses: Darier disease: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Genodermatoses: Darier disease

Sample item

A young adult has greasy, keratotic brown papules over the seborrhoeic areas, V-shaped nail nicking and worsening in summer. Histology shows corps ronds and grains. Which gene is involved?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. ATP2A2

Darier disease is an autosomal dominant disorder from mutations in ATP2A2, which encodes the SERCA2 calcium pump of the endoplasmic reticulum. Oral retinoids help severe disease.

Option by option

  • A. KRT5

    KRT5 causes epidermolysis bullosa simplex.

  • B. FLG

    FLG mutations cause ichthyosis vulgaris.

  • C. ATP2A2 (correct)

    Correct. ATP2A2 mutation causes Darier disease.

  • D. ATP2C1

    ATP2C1 causes Hailey-Hailey disease.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is C, ATP2A2. Darier disease is an autosomal dominant disorder from mutations in ATP2A2, which encodes the SERCA2 calcium pump of the endoplasmic reticulum.

Why is "KRT5" not the answer?

KRT5 causes epidermolysis bullosa simplex.

Why is "FLG" not the answer?

FLG mutations cause ichthyosis vulgaris.

Why is "ATP2C1" not the answer?

ATP2C1 causes Hailey-Hailey disease.

What concept does this question test?

It tests Genodermatoses: Darier disease in Dermatology. Oral retinoids help severe disease.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Genodermatoses: Darier disease?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.