Oral pathology: cherubism: practice question

A Dentistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dentistry · Oral pathology: cherubism

Sample item

A 4-year-old boy has painless symmetrical swelling of both mandibular angles and an upturned gaze with scleral show. Radiographs show bilateral multilocular lesions. Which gene is involved?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. SH3BP2

Cherubism is an autosomal dominant condition caused by SH3BP2 mutation, with bilateral multilocular giant-cell lesions of the jaws that usually regress after puberty. Eye findings arise from orbital floor involvement.

Option by option

  • A. PTCH1

    PTCH1 mutation causes Gorlin syndrome.

  • B. GNAS

    GNAS mutation causes fibrous dysplasia, usually unilateral.

  • C. SH3BP2 (correct)

    Correct. SH3BP2 mutation causes cherubism.

  • D. FGFR3

    FGFR3 mutation causes achondroplasia.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dentistry question

What is the answer to this Dentistry question?

The best answer is C, SH3BP2. Cherubism is an autosomal dominant condition caused by SH3BP2 mutation, with bilateral multilocular giant-cell lesions of the jaws that usually regress after puberty.

Why is "PTCH1" not the answer?

PTCH1 mutation causes Gorlin syndrome.

Why is "GNAS" not the answer?

GNAS mutation causes fibrous dysplasia, usually unilateral.

Why is "FGFR3" not the answer?

FGFR3 mutation causes achondroplasia.

What concept does this question test?

It tests Oral pathology: cherubism in Dentistry. Eye findings arise from orbital floor involvement.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Oral pathology: cherubism?

Learn the dental formula, eruption ages and tooth structure once, as tables. Then use the flashcards and the other Dentistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.