Oral medicine: Peutz-Jeghers syndrome: practice question

A Dentistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dentistry · Oral medicine: Peutz-Jeghers syndrome

Sample item

A child has dark macules on the lips and buccal mucosa and has had recurrent intussusception. Which condition and gene are involved?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Peutz-Jeghers syndrome, STK11

Peutz-Jeghers syndrome combines perioral and buccal mucocutaneous pigmentation with hamartomatous gastrointestinal polyps that cause intussusception. It results from STK11 mutation and raises cancer risk.

Option by option

  • A. Peutz-Jeghers syndrome, STK11 (correct)

    Correct. Pigmented lips and polyps point to STK11.

  • B. Addison disease, CYP21A2

    Addison disease causes diffuse pigmentation without polyps.

  • C. Gardner syndrome, APC

    Gardner syndrome has adenomatous polyps, osteomas and desmoids.

  • D. Cowden syndrome, PTEN

    Cowden syndrome shows trichilemmomas and papules.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dentistry question

What is the answer to this Dentistry question?

The best answer is A, Peutz-Jeghers syndrome, STK11. Peutz-Jeghers syndrome combines perioral and buccal mucocutaneous pigmentation with hamartomatous gastrointestinal polyps that cause intussusception.

Why is "Addison disease, CYP21A2" not the answer?

Addison disease causes diffuse pigmentation without polyps.

Why is "Gardner syndrome, APC" not the answer?

Gardner syndrome has adenomatous polyps, osteomas and desmoids.

Why is "Cowden syndrome, PTEN" not the answer?

Cowden syndrome shows trichilemmomas and papules.

What concept does this question test?

It tests Oral medicine: Peutz-Jeghers syndrome in Dentistry. It results from STK11 mutation and raises cancer risk.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Oral medicine: Peutz-Jeghers syndrome?

Learn the dental formula, eruption ages and tooth structure once, as tables. Then use the flashcards and the other Dentistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.