Vesiculobullous disorders: localised epidermolysis bullosa simplex: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · Vesiculobullous disorders: localised epidermolysis bullosa simplex

Sample item

A recruit has tense blisters on the soles after long route marches in summer. He has had the same problem since childhood and his father is affected. There is no mucosal involvement. Which proteins are defective?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Keratin 5 and keratin 14

Localised epidermolysis bullosa simplex (Weber-Cockayne) causes friction blisters on hands and feet, worse in hot weather, from keratin 5 or 14 defects. Basal keratinocytes fragment and the split is intraepidermal.

Option by option

  • A. Keratin 1 and keratin 10

    Keratin 1 and 10 defects cause epidermolytic hyperkeratosis.

  • B. Keratin 5 and keratin 14 (correct)

    Correct. Keratin 5 and 14 defects cause epidermolysis bullosa simplex.

  • C. Collagen VII

    Collagen VII is defective in dystrophic epidermolysis bullosa, with scarring.

  • D. Laminin 332

    Laminin 332 is defective in junctional epidermolysis bullosa, with a lamina lucida split.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is B, Keratin 5 and keratin 14. Localised epidermolysis bullosa simplex (Weber-Cockayne) causes friction blisters on hands and feet, worse in hot weather, from keratin 5 or 14 defects.

Why is "Keratin 1 and keratin 10" not the answer?

Keratin 1 and 10 defects cause epidermolytic hyperkeratosis.

Why is "Collagen VII" not the answer?

Collagen VII is defective in dystrophic epidermolysis bullosa, with scarring.

Why is "Laminin 332" not the answer?

Laminin 332 is defective in junctional epidermolysis bullosa, with a lamina lucida split.

What concept does this question test?

It tests Vesiculobullous disorders: localised epidermolysis bullosa simplex in Dermatology. Basal keratinocytes fragment and the split is intraepidermal.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Vesiculobullous disorders: localised epidermolysis bullosa simplex?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.