Oral medicine and oral cancer: granulomatosis with polyangiitis: practice question

A Dentistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dentistry · Oral medicine and oral cancer: granulomatosis with polyangiitis

Sample item

A 40-year-old has red, granular, strawberry-like gingival hyperplasia, a saddle-nose deformity, crusting nasal discharge and haematuria. Which antibody is most characteristic of this disease?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. c-ANCA directed against proteinase 3

Strawberry gingivitis with nasal destruction and kidney involvement suggests granulomatosis with polyangiitis, which is typically c-ANCA (PR3) positive.

Option by option

  • A. Anti-Ro (SSA)

    Anti-Ro is linked to Sjogren syndrome.

  • B. Anti-double-stranded DNA

    Anti-dsDNA is a marker of lupus.

  • C. c-ANCA directed against proteinase 3 (correct)

    Correct. c-ANCA to PR3 is characteristic.

  • D. p-ANCA directed against myeloperoxidase

    p-ANCA to MPO is typical of microscopic polyangiitis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dentistry question

What is the answer to this Dentistry question?

The best answer is C, c-ANCA directed against proteinase 3. Strawberry gingivitis with nasal destruction and kidney involvement suggests granulomatosis with polyangiitis, which is typically c-ANCA (PR3) positive.

Why is "Anti-Ro (SSA)" not the answer?

Anti-Ro is linked to Sjogren syndrome.

Why is "Anti-double-stranded DNA" not the answer?

Anti-dsDNA is a marker of lupus.

Why is "p-ANCA directed against myeloperoxidase" not the answer?

p-ANCA to MPO is typical of microscopic polyangiitis.

What concept does this question test?

It tests Oral medicine and oral cancer: granulomatosis with polyangiitis in Dentistry. The correct option holds because: Correct. c-ANCA to PR3 is characteristic.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Oral medicine and oral cancer: granulomatosis with polyangiitis?

Learn the dental formula, eruption ages and tooth structure once, as tables. Then use the flashcards and the other Dentistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.