Neuro-ophthalmology and pupils: teprotumumab: practice question

A Ophthalmology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Ophthalmology · Neuro-ophthalmology and pupils: teprotumumab

Sample item

A 42-year-old woman with active moderate to severe thyroid eye disease has proptosis and diplopia not controlled by earlier measures. Which targeted drug can reduce proptosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Teprotumumab

Teprotumumab blocks the insulin-like growth factor-1 receptor on orbital fibroblasts and reduces proptosis and diplopia. Ranibizumab is anti-VEGF. Methimazole treats hyperthyroidism but not the orbitopathy, and radioiodine can worsen eye disease.

Option by option

  • A. Ranibizumab

    Ranibizumab is an anti-VEGF agent not used for thyroid orbitopathy.

  • B. Radioiodine

    Radioiodine can aggravate eye disease and is not a treatment for it.

  • C. Methimazole

    Methimazole controls thyroid hormone levels, not the orbital inflammation.

  • D. Teprotumumab (correct)

    Correct. Teprotumumab blocks the IGF-1 receptor in orbital fibroblasts.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Ophthalmology questions

Questions about this Ophthalmology question

What is the answer to this Ophthalmology question?

The best answer is D, Teprotumumab. Teprotumumab blocks the insulin-like growth factor-1 receptor on orbital fibroblasts and reduces proptosis and diplopia.

Why is "Ranibizumab" not the answer?

Ranibizumab is an anti-VEGF agent not used for thyroid orbitopathy.

Why is "Radioiodine" not the answer?

Radioiodine can aggravate eye disease and is not a treatment for it.

Why is "Methimazole" not the answer?

Methimazole controls thyroid hormone levels, not the orbital inflammation.

What concept does this question test?

It tests Neuro-ophthalmology and pupils: teprotumumab in Ophthalmology. Ranibizumab is anti-VEGF. Methimazole treats hyperthyroidism but not the orbitopathy, and radioiodine can worsen eye disease.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neuro-ophthalmology and pupils: teprotumumab?

Group the red eye by what to examine and what the pupil does. Then use the flashcards and the other Ophthalmology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.