Neoplasia: RB protein: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Neoplasia: RB protein

Sample item

The retinoblastoma protein normally restrains cell proliferation by binding which transcription factor?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. E2F

Hypophosphorylated RB binds E2F and prevents transcription of S-phase genes. Cyclin D-CDK4 phosphorylation releases E2F, permitting G1-to-S progression.

Option by option

  • A. NF-kappaB

    NF-kappaB regulates inflammatory and survival genes.

  • B. HIF-1 alpha

    HIF-1 alpha mediates hypoxic responses.

  • C. STAT6

    STAT6 participates in IL-4 signalling.

  • D. E2F (correct)

    Correct. RB-E2F binding is the G1/S checkpoint mechanism.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is D, E2F. Hypophosphorylated RB binds E2F and prevents transcription of S-phase genes.

Why is "NF-kappaB" not the answer?

NF-kappaB regulates inflammatory and survival genes.

Why is "HIF-1 alpha" not the answer?

HIF-1 alpha mediates hypoxic responses.

Why is "STAT6" not the answer?

STAT6 participates in IL-4 signalling.

What concept does this question test?

It tests Neoplasia: RB protein in Pathology. Cyclin D-CDK4 phosphorylation releases E2F, permitting G1-to-S progression.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Neoplasia: RB protein?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.