Renal pathology: diabetic nephropathy: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Renal pathology: diabetic nephropathy

Sample item

Nodular glomerulosclerosis in long-standing diabetes mellitus is known by which eponym?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Kimmelstiel-Wilson lesion

Diabetic nephropathy produces diffuse mesangial expansion and nodular glomerulosclerosis, termed Kimmelstiel-Wilson lesions. Persistent albuminuria is an important clinical marker.

Option by option

  • A. Aschoff body

    Aschoff bodies occur in rheumatic carditis.

  • B. Kimmelstiel-Wilson lesion (correct)

    Correct. Kimmelstiel-Wilson nodules are diabetic glomerular lesions.

  • C. Councilman body

    Councilman bodies are apoptotic hepatocytes in viral hepatitis.

  • D. Mallory-Denk body

    Mallory-Denk bodies occur in alcoholic and some metabolic liver diseases.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is B, Kimmelstiel-Wilson lesion. Diabetic nephropathy produces diffuse mesangial expansion and nodular glomerulosclerosis, termed Kimmelstiel-Wilson lesions.

Why is "Aschoff body" not the answer?

Aschoff bodies occur in rheumatic carditis.

Why is "Councilman body" not the answer?

Councilman bodies are apoptotic hepatocytes in viral hepatitis.

Why is "Mallory-Denk body" not the answer?

Mallory-Denk bodies occur in alcoholic and some metabolic liver diseases.

What concept does this question test?

It tests Renal pathology: diabetic nephropathy in Pathology. Persistent albuminuria is an important clinical marker.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Renal pathology: diabetic nephropathy?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.