Autoimmunity: type II hypersensitivity: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Autoimmunity: type II hypersensitivity

Sample item

Autoimmune hemolytic anemia caused by antibodies against red-cell surface antigens is which type of hypersensitivity?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Type II

Type II hypersensitivity is antibody mediated against cell-surface or matrix antigens, causing complement activation, phagocytosis, or receptor dysfunction. Autoimmune hemolysis is a classic example.

Option by option

  • A. Type I

    Type I is immediate IgE-mediated allergy.

  • B. Type IV

    Type IV is T-cell-mediated delayed hypersensitivity.

  • C. Type II (correct)

    Correct. IgG or IgM against red-cell surfaces causes type II injury.

  • D. Type III

    Type III is immune-complex deposition.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Type II. Type II hypersensitivity is antibody mediated against cell-surface or matrix antigens, causing complement activation, phagocytosis, or receptor dysfunction.

Why is "Type I" not the answer?

Type I is immediate IgE-mediated allergy.

Why is "Type IV" not the answer?

Type IV is T-cell-mediated delayed hypersensitivity.

Why is "Type III" not the answer?

Type III is immune-complex deposition.

What concept does this question test?

It tests Autoimmunity: type II hypersensitivity in Pathology. Autoimmune hemolysis is a classic example.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Autoimmunity: type II hypersensitivity?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.