Hematopathology: multiple myeloma: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Pathology · Hematopathology: multiple myeloma

Sample item

A patient has bone pain, lytic lesions, anemia, renal impairment, and high total protein. Which malignancy is most likely?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Multiple myeloma

Multiple myeloma is a clonal plasma-cell neoplasm causing CRAB features: hypercalcemia, renal impairment, anemia, and bone lesions. Monoclonal protein studies and marrow assessment establish diagnosis.

Option by option

  • A. Hodgkin lymphoma

    Hodgkin lymphoma typically presents with lymphadenopathy and Reed-Sternberg cells.

  • B. Acute lymphoblastic leukemia

    ALL presents with marrow failure and lymphoblasts, often in children.

  • C. Essential thrombocythemia

    Essential thrombocythemia is a myeloproliferative disorder with elevated platelets.

  • D. Multiple myeloma (correct)

    Correct. Lytic bone disease with anemia, renal dysfunction, and paraprotein suggests myeloma.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is D, Multiple myeloma. Multiple myeloma is a clonal plasma-cell neoplasm causing CRAB features: hypercalcemia, renal impairment, anemia, and bone lesions.

Why is "Hodgkin lymphoma" not the answer?

Hodgkin lymphoma typically presents with lymphadenopathy and Reed-Sternberg cells.

Why is "Acute lymphoblastic leukemia" not the answer?

ALL presents with marrow failure and lymphoblasts, often in children.

Why is "Essential thrombocythemia" not the answer?

Essential thrombocythemia is a myeloproliferative disorder with elevated platelets.

What concept does this question test?

It tests Hematopathology: multiple myeloma in Pathology. Monoclonal protein studies and marrow assessment establish diagnosis.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Hematopathology: multiple myeloma?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.