Gastrointestinal pathology: stomach: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Gastrointestinal pathology: stomach

Sample item

Chronic Helicobacter pylori gastritis with intestinal metaplasia is the precursor of which carcinoma?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Intestinal-type gastric adenocarcinoma

The Correa cascade runs from chronic gastritis through atrophy and intestinal metaplasia to dysplasia and intestinal-type adenocarcinoma. Diffuse-type cancer is associated with E-cadherin (CDH1) loss and not with metaplasia.

Option by option

  • A. Intestinal-type gastric adenocarcinoma (correct)

    Correct. Intestinal metaplasia leads to glandular adenocarcinoma.

  • B. Gastric MALT lymphoma (marginal zone type)

    H. pylori drives MALT lymphoma from acquired lymphoid tissue, not from intestinal metaplasia.

  • C. Diffuse-type gastric adenocarcinoma with signet ring cells

    Diffuse type is associated with CDH1 loss and linitis plastica.

  • D. Gastrointestinal stromal tumour

    GIST arises from interstitial cells of Cajal with KIT mutation.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is A, Intestinal-type gastric adenocarcinoma. The Correa cascade runs from chronic gastritis through atrophy and intestinal metaplasia to dysplasia and intestinal-type adenocarcinoma.

Why is "Gastric MALT lymphoma (marginal zone type)" not the answer?

H. pylori drives MALT lymphoma from acquired lymphoid tissue, not from intestinal metaplasia.

Why is "Diffuse-type gastric adenocarcinoma with signet ring cells" not the answer?

Diffuse type is associated with CDH1 loss and linitis plastica.

Why is "Gastrointestinal stromal tumour" not the answer?

GIST arises from interstitial cells of Cajal with KIT mutation.

What concept does this question test?

It tests Gastrointestinal pathology: stomach in Pathology. Diffuse-type cancer is associated with E-cadherin (CDH1) loss and not with metaplasia.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gastrointestinal pathology: stomach?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.