Inflammation and repair: neutrophil granule contents: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Pathology · Inflammation and repair: neutrophil granule contents

Sample item

Neutrophils contain two main granule types. Which constituent is found in the azurophil (primary) granules?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Myeloperoxidase

Azurophil granules contain myeloperoxidase, defensins, elastase, bactericidal permeability-increasing protein and lysozyme. Specific (secondary) granules contain lactoferrin, collagenase, gelatinase and lysozyme. Azurophil granules are the larger, earlier-formed granules that stain with peroxidase.

Option by option

  • A. Gelatinase

    Gelatinase is stored in specific or tertiary granules.

  • B. Collagenase

    Collagenase is a content of specific granules.

  • C. Myeloperoxidase (correct)

    Correct. Myeloperoxidase is the marker enzyme of azurophil granules.

  • D. Lactoferrin

    Lactoferrin is a characteristic content of specific granules.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pathology questions

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Myeloperoxidase. Azurophil granules contain myeloperoxidase, defensins, elastase, bactericidal permeability-increasing protein and lysozyme.

Why is "Gelatinase" not the answer?

Gelatinase is stored in specific or tertiary granules.

Why is "Collagenase" not the answer?

Collagenase is a content of specific granules.

Why is "Lactoferrin" not the answer?

Lactoferrin is a characteristic content of specific granules.

What concept does this question test?

It tests Inflammation and repair: neutrophil granule contents in Pathology. Specific (secondary) granules contain lactoferrin, collagenase, gelatinase and lysozyme. Azurophil granules are the larger, earlier-formed granules that stain with peroxidase.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation and repair: neutrophil granule contents?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.