Inflammation and repair: delayed prolonged vascular leakage: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Inflammation and repair: delayed prolonged vascular leakage

Sample item

A fair-skinned man develops swelling and redness of his shoulders about 8 hours after severe sunburn. The oedema persists for several days. Which pattern of vascular leakage accounts for this?

ALeakage through channels formed by VEGF-induced transcytosisBDelayed prolonged leakage from venules and capillariesCImmediate sustained leakage from necrotic endothelium of venulesDImmediate transient leakage from venules by endothelial contraction

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Delayed prolonged leakage from venules and capillaries

In delayed prolonged leakage, permeability rises after a lag of 2 to 12 hours and lasts for hours to days, involving venules and capillaries. It follows mild thermal injury, ultraviolet radiation and some bacterial toxins. Histamine-induced contraction is immediate and brief, and severe burns cause immediate sustained leakage.

Option by option

A. Leakage through channels formed by VEGF-induced transcytosis
Transcytosis through VEGF-induced channels increases permeability but does not produce this delayed pattern.
B. Delayed prolonged leakage from venules and capillaries (correct)
Correct. Late onset with prolonged duration is typical of sunburn.
C. Immediate sustained leakage from necrotic endothelium of venules
Immediate sustained leakage follows severe direct injury such as full-thickness burns.
D. Immediate transient leakage from venules by endothelial contraction
Immediate transient leakage follows histamine within minutes and subsides in under an hour.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is B, Delayed prolonged leakage from venules and capillaries. In delayed prolonged leakage, permeability rises after a lag of 2 to 12 hours and lasts for hours to days, involving venules and capillaries.

Why is "Leakage through channels formed by VEGF-induced transcytosis" not the answer?

Transcytosis through VEGF-induced channels increases permeability but does not produce this delayed pattern.

Why is "Immediate sustained leakage from necrotic endothelium of venules" not the answer?

Immediate sustained leakage follows severe direct injury such as full-thickness burns.

Why is "Immediate transient leakage from venules by endothelial contraction" not the answer?

Immediate transient leakage follows histamine within minutes and subsides in under an hour.

What concept does this question test?

It tests Inflammation and repair: delayed prolonged vascular leakage in Pathology. It follows mild thermal injury, ultraviolet radiation and some bacterial toxins. Histamine-induced contraction is immediate and brief, and severe burns cause immediate sustained leakage.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation and repair: delayed prolonged vascular leakage?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.