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Dermatology · HIV: oral hairy leukoplakia
Sample itemAn HIV positive patient has white corrugated plaques on the lateral border of the tongue that cannot be scraped off. Which virus is implicated?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Epstein-Barr virus
Oral hairy leukoplakia is caused by EBV replication in tongue epithelium, usually with CD4 counts under 300 to 500, and indicates progression of HIV. It does not scrape off, unlike candidiasis.
Option by option
A. Epstein-Barr virus (correct)
Correct. EBV causes oral hairy leukoplakia.
B. Candida albicans
Candida plaques scrape off, leaving erythema.
C. Cytomegalovirus
CMV causes ulcers in advanced disease.
D. Human papillomavirus 16
HPV causes warts and papillomas.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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