HIV: first-line antiretroviral therapy: practice question

A Dermatology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dermatology · HIV: first-line antiretroviral therapy

Sample item

Which fixed-dose combination is the preferred first-line antiretroviral regimen under the Indian national programme?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Tenofovir, lamivudine and dolutegravir

The national programme uses tenofovir plus lamivudine plus dolutegravir (TLD) once daily as first-line therapy. Older regimens with stavudine or nevirapine have been replaced because of toxicity or lower efficacy.

Option by option

  • A. Zidovudine, lamivudine and nevirapine

    AZT, 3TC and NVP is an older regimen.

  • B. Stavudine, lamivudine and nevirapine

    Stavudine-based regimens are phased out due to toxicity.

  • C. Tenofovir, lamivudine and dolutegravir (correct)

    Correct. TLD is the preferred first-line regimen.

  • D. Abacavir, didanosine and ritonavir

    This combination is not a standard regimen.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dermatology question

What is the answer to this Dermatology question?

The best answer is C, Tenofovir, lamivudine and dolutegravir. The national programme uses tenofovir plus lamivudine plus dolutegravir (TLD) once daily as first-line therapy.

Why is "Zidovudine, lamivudine and nevirapine" not the answer?

AZT, 3TC and NVP is an older regimen.

Why is "Stavudine, lamivudine and nevirapine" not the answer?

Stavudine-based regimens are phased out due to toxicity.

Why is "Abacavir, didanosine and ritonavir" not the answer?

This combination is not a standard regimen.

What concept does this question test?

It tests HIV: first-line antiretroviral therapy in Dermatology. Older regimens with stavudine or nevirapine have been replaced because of toxicity or lower efficacy.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study HIV: first-line antiretroviral therapy?

Learn each condition by its primary lesion, site and signature sign. Then use the flashcards and the other Dermatology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.