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Pathology · Hemodynamic disorders: chronic congestion
Sample itemWhich histologic finding is expected in chronic passive congestion of the liver from right-sided heart failure?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Centrilobular congestion and necrosis
Right-sided heart failure causes chronic hepatic venous congestion, greatest around central veins, producing centrilobular hypoxia and necrosis. Grossly this can create a nutmeg appearance.
Option by option
A. Diffuse fatty replacement of all hepatocytes only
Fatty change may occur but does not define congestive hepatopathy.
B. Amyloid in portal tracts
Amyloid deposition is a separate protein-accumulation disorder.
C. Centrilobular congestion and necrosis (correct)
Correct. Zone 3 is most vulnerable to venous congestion and hypoxia.
D. Caseating granulomas
Caseation is typical of tuberculosis.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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