Inflammation: leukocyte defect: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Inflammation: leukocyte defect

Sample item

A child has delayed separation of the umbilical cord, recurrent bacterial infections without pus, and persistent neutrophilia. What defect is likely?

ALeukocyte adhesion deficiencyBChronic granulomatous diseaseCComplement C1 esterase deficiencyDChediak-Higashi syndrome

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Leukocyte adhesion deficiency

Leukocyte adhesion deficiency impairs integrin-mediated neutrophil adhesion and transmigration, causing delayed cord separation, absent pus, recurrent infections, and neutrophilia in blood.

Option by option

A. Leukocyte adhesion deficiency (correct)
Correct. Failed neutrophil extravasation produces this classic pattern.
B. Chronic granulomatous disease
CGD causes defective respiratory burst and catalase-positive infections.
C. Complement C1 esterase deficiency
C1 esterase deficiency causes hereditary angioedema.
D. Chediak-Higashi syndrome
Chediak-Higashi causes lysosomal trafficking defect with albinism and neuropathy.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is A, Leukocyte adhesion deficiency. Leukocyte adhesion deficiency impairs integrin-mediated neutrophil adhesion and transmigration, causing delayed cord separation, absent pus, recurrent infections, and neutrophilia in blood.

Why is "Chronic granulomatous disease" not the answer?

CGD causes defective respiratory burst and catalase-positive infections.

Why is "Complement C1 esterase deficiency" not the answer?

C1 esterase deficiency causes hereditary angioedema.

Why is "Chediak-Higashi syndrome" not the answer?

Chediak-Higashi causes lysosomal trafficking defect with albinism and neuropathy.

What concept does this question test?

It tests Inflammation: leukocyte defect in Pathology. The correct option holds because: Correct. Failed neutrophil extravasation produces this classic pattern.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Inflammation: leukocyte defect?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.