Hemostasis: hemophilia: practice question

A Pathology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pathology · Hemostasis: hemophilia

Sample item

Which laboratory pattern is most typical of hemophilia A?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Prolonged aPTT with normal PT and normal platelet count

Hemophilia A is factor VIII deficiency affecting the intrinsic pathway, so aPTT is prolonged while PT and platelet count are generally normal. Clinical bleeding is typically deep-tissue and joint bleeding.

Option by option

  • A. Prolonged PT only with thrombocytopenia

    PT and thrombocytopenia suggest different disorders.

  • B. Shortened bleeding time only

    Bleeding time is usually normal because platelets are normal.

  • C. Prolonged aPTT with normal PT and normal platelet count (correct)

    Correct. Intrinsic-pathway factor deficiency prolongs aPTT.

  • D. Normal aPTT with high D-dimer only

    High D-dimer is not the defining hemophilia pattern.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Pathology question

What is the answer to this Pathology question?

The best answer is C, Prolonged aPTT with normal PT and normal platelet count. Hemophilia A is factor VIII deficiency affecting the intrinsic pathway, so aPTT is prolonged while PT and platelet count are generally normal.

Why is "Prolonged PT only with thrombocytopenia" not the answer?

PT and thrombocytopenia suggest different disorders.

Why is "Shortened bleeding time only" not the answer?

Bleeding time is usually normal because platelets are normal.

Why is "Normal aPTT with high D-dimer only" not the answer?

High D-dimer is not the defining hemophilia pattern.

What concept does this question test?

It tests Hemostasis: hemophilia in Pathology. Clinical bleeding is typically deep-tissue and joint bleeding.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Hemostasis: hemophilia?

Learn each disease as a bundle: cause, key histology, markers, and the clinical hallmark. Then use the flashcards and the other Pathology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.